Additionally, it appears that DNA repair is inhibited only in cells that have a massive overexpression of the spike protein. So any measurable effect alluded to here could in fact represent a highly exaggerated version of it. These systems will produce levels of the spike protein in cells orders of magnitude higher and for longer than the vaccines. First of all these studies were performed in vitro using overexpression systems. This is one possible interpretation, but I'd say it's pretty unlikely. "Ģ) "Our findings reveal a potential molecular mechanism by which the spike protein might impede adaptive immunity and underscore the potential side effects of full-length spike-based vaccines."ģ) "Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein."Ĥ) "In contrast, our data provide valuable details on the involvement of spike protein subunits in DNA damage repair, indicating that full–length spike–based vaccines may inhibit the recombination of V(D)J in B cells, which is also consistent with a recent study that a full–length spike–based vaccine induced lower antibody titers compared to the RBD–based vaccine " I got the vaccine but here is what the scientists are saying in the study, direct quotes.ġ) "To date, many approved SARS–CoV–2 vaccines, such as mRNA vaccines and adenovirus–COVID–19 vaccines, have been developed based on the full–length spike protein. It definitely warrants follow-up studies in my mind. B or T cells), so it is at best indirect evidence of a possible mechanism for inhibition of the adaptive immune response to SARS-CoV-2. However, they are also done in cells that are not immune cells (i.e. These findings are independent of each other, and, when taken together, you can hypothesize that this inhibition of V(D)J DNA recombination does occur in the nucleus of the cells. Spike protein expressed in these cells can localize to the nucleus, and, therefore, can possibly mess with the DNA in there. In the cytosol of the cell, spike protein inhibits proteins involved with a certain type of DNA repair and recombination that is necessary for the evolution of antibodies (VDJ recombination) 2. What is show in this paper is that in an embryonic human kidney cell line (HEK293), 1. This paper aims to provide evidence for a possible mechanism/explanation for observations of a delayed and weak adaptive immune response to SARS-CoV-2 in patients with severe cases. New to reddit? Click here! Get flair in /r/science Previous Science AMA's Repeat or flagrant offenders will be banned.Comments dismissing established findings and fields of science must provide evidence.Criticism of published work should assume basic competence of the researchers and reviewers.Non-professional personal anecdotes will be removed.No off-topic comments, memes, low-effort comments or jokes. ![]()
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